Ben’s Peptide Stack for Restoration, Explosive Beneficial properties, & Ageless Vitality

September 17, 2024

Peptides—quick chains of amino acids which are the “constructing blocks” of proteins—might be extraordinarily efficient for concentrating on a single pathway or mechanism within the physique with nice precision. For instance, BPC-157 can assist you get better sooner by quelling irritation, LL-37 can help a greater immune system and squash a bout of SIBO, giardia, or different intestine points, and Semax might be efficient as a potent nootropic or sensible drug equal for cognitive efficiency.

Once you “stack” a number of peptides, nonetheless, and use them collectively in a multi-targeted strategy for a broader well being purpose, their advantages can compound and turn into much more highly effective—typically serving to you expertise important enchancment in a a lot shorter time frame.

However with regards to which peptides work collectively, these you may stack collectively safely and successfully, what doses to make use of, and the way typically to take every—issues can get a bit complicated, to say the very least.

So on this article, I’m going to interrupt down the most effective peptide stacks (together with a number of that I’ve used efficiently myself) to focus on restoration, muscle acquire, fats loss, immunity, anti-aging, and extra.

I’ll additionally cowl beneficial tips for dosing every peptide, the frequency they need to be administered, whether or not peptides ought to be cycled on and off in the course of the 12 months, the most effective time of day to take peptides, and far more!

Disclaimer: I’m not a health care provider and this isn’t to be taken, interpreted, or construed as medical recommendation. These are simply my private ideas and never a prescription, a prognosis, or any type of well being care in any way. Please discuss with a licensed medical skilled in the event you’re fascinated about utilizing peptides. As of now, peptide remedy is taken into account “experimental” and lacks medical long-term analysis, so you must proceed at your individual threat. As well as, most of these things is banned by the World Anti-Doping Affiliation (WADA), US Anti-Doping Affiliation (USADA), and different worldwide governing our bodies of sport, so you shouldn’t use any of those compounds if you’re competing in any sanctioned sport. Additionally, please observe that the world of peptides is ever-evolving, and whereas I do attempt to hold posted articles up to date, I can solely attest that this data is present as of September 2024. To examine in case your peptide is authorized, go to globaldro.com, choose your nation, and have the identify of the medicine readily available to see if it is banned in any athletic sport. 

The Finest Peptide Stacks for Your Well being Objectives

Now, earlier than I bounce headfirst into the peptide stacking deep finish, let me give only one extra fast disclaimer (isn’t this authorized stuff enjoyable?!)…

…the dosing and frequency suggestions supplied beneath are merely basic tips.

Like every medicine or complement, peptide doses will change based mostly in your physique weight, measurement, and private well being standing. I like to recommend you begin on the decrease finish of a peptide dose and frequency to see the way you personally reply. Above all, you must observe the directions out of your doctor or peptide producer.

I might additionally extremely suggest that you just overview the detailed directions for reconstitution, storage, and administration supplied on this article earlier than continuing.

The “Get better Like Wolverine” Peptide Stack

Certainly one of my first critical forays into peptides was to heal an annoying, persistent, and fairly painful torn higher hamstring through the use of what I name the “Get better Like Wolverine” stack.

And it labored—with fairly stunning pace, no much less.

So when you have irritating joint ache that will not go away, some type of muscle tear or sprain, or just need to improve your athletic restoration, this peptide stack beats the pants off your typical old-school “R.I.C.E.” protocol (relaxation, ice, compression, and elevation).

This potent restoration stack incorporates the next peptides: BPC-157, TB-500, ipamorelin, tesamorelin, and GHK-Cu.

BPC-157

Remoted from a bigger peptide generally known as “physique defending compound,” which is of course present in human gastric juice, BPC-157 has quite a few advantages. These embrace regenerative results reminiscent of therapeutic muscle tissue, tendons, ligaments, bones, and pores and skin burns, in addition to growing blood move via angiogenesis and providing highly effective anti-inflammatory properties. It will also be taken orally—firms reminiscent of CanLab, Peptide Sciences, Limitless Life, and LVLUP Well being have entry to oral variations of BPC-157 and a number of other of the opposite peptides listed beneath. 

The directions beneath embrace tips in the event you’re taking oral tablets.

• Dosing Pointers:
  • Injection: 250–350mcg 2x/day; OR
  • Injection: 500–700 mcg 1x/day; OR
  • Injection: 0.15mL of 2000mcg/mL answer each day for a 30-day cycle; OR
  • Oral: 500mcg capsules for a 30-day cycle
• Administration Route:
  • Subcutaneous injection for systemic therapeutic
  • Intramuscular injection for focused therapeutic
  • Orally for intestine therapeutic or comfort

Once more, you may click on right here for dosing/reconstituting directions. Sadly, as of January 1, 2022, the World Anti-Doping Company listed BPC-157 as a prohibited substance, which means athletes topic to WADA rules are not allowed to make use of it in competitors or coaching, because it may end in disqualification or penalties.

TB-500 (Thymosin Beta-4)

TB-500 is a naturally produced peptide present in almost each a part of the human physique. It will increase the exercise of the muscle protein actin to advertise mobile development and stimulate blood cell growth and has been proven to restore injury to the guts, pores and skin, tissue, ligaments, and different organs and supply ache aid. It’s most likely the most effective peptide for muscle restore, nonetheless, TB-500 is banned by WADA and most different world sporting organizations each in-competition and out-of-competition.

But, in the event you’re trying to promote wound restore and therapeutic, it’s an unbelievable answer as a result of it acts on actin and myosin fibers in tendons, ligaments, and muscle tissue—which can also be seemingly why this peptide is used as a preferred therapeutic and restoration technique within the horse-racing trade.

• Dosing Pointers: Please observe that there are only a few tips round dosing TB-500, so it’s greatest to observe your practitioner or producer’s options. Nevertheless, here’s what I’ve used:
  • 5-2.5 mg, 2–3x/week; OR
  • 25mL of 3000mcg/mL answer every day for a 20-day cycle
• Administration Route:
  • Subcutaneous or intramuscular injection

Ipamorelin

Ipamorelin enhances restoration via the activation of human development hormone (generally known as a “development hormone secretagogue”), which is well-known to speed up the therapeutic course of. In contrast to utilizing human development hormone (HGH) immediately, nonetheless, ipamorelin—when used at applicable doses—seems to be comparatively freed from unwanted side effects and won’t have an effect on or intervene together with your physique’s pure manufacturing of GH.

• Dosing Pointers:
  • 100-500mcg 1-3x/day; OR
  • 10mL of 2000mcg/mL answer 1x/day, 5 days per week
• Administration Route:
• Timing Ideas:
  • For greatest outcomes, it is suggested to manage ipamorelin on the identical time every day and keep away from consuming meals and huge quantities of liquids a minimum of 1 hour earlier than and after.

Tesamorelin

Tesamorelin is like ipamorelin’s cousin; it promotes restoration via the identical GH pathways, serving as a “development hormone stimulating hormone.” In different phrases, it binds to and stimulates development hormone receptors with comparable efficiency as taking endogenous HGH—once more, with out the undesirable unwanted side effects.

• Dosing Pointers:
  • 1mg 1–2x/day for five days per week for a 6–8 week cycle; OR
  • 5mL of 1mg/0.6mL answer 1x/day, 6 days per week for a 6–8 week cycle
• Administration Route:
• Timing Ideas:
  • Earlier than mattress, take it a minimum of 90 minutes after consuming. Upon waking, take tesamorelin ideally earlier than train and consuming.

GHK-Cu

GHK-Cu is a naturally occurring copper advanced present in human plasma, saliva, and urine. It has many roles within the physique, together with selling restoration. It appears to behave as an anti-inflammatory agent that controls oxidative injury post-tissue damage, in addition to signaling tissue reworking and the technology of latest, wholesome tissue. Whereas GHK-Cu is greatest injected subcutaneously for restoration, it will also be used topically/transdermally for different functions like pores and skin well being or hair regrowth—such because the case with Jay Campbell’s hair regrowth peptide components.

• Dosing Pointers:
  • 5mg 1x/day for a 5–10 day cycle; OR
  • 2mL of 10mg/mL answer 2x/day
• Administration Route:

Here’s a checklist of assets to find much more about these particular peptides:

• How To Use BPC-157: A Full Dummies Information To Therapeutic The Physique Like Wolverine.
• How To Construct New Blood Vessels, Regenerate Muscle Tissue Fibers, Improve New Cell Progress & Extra With One thing Known as “TB-500.”
• Demystifying Progress Hormone-Releasing Peptides – All the things You Want To Know About GH, Ipamorelin, Tesamorelin & Extra!
• The Coolest, Craziest Peptides You’ve By no means Heard Of (& The place To Get Them), Boosting Testosterone With out Medicine, The Latest Creatine Booster & Extra With LVLUP Well being’s Kyal Van Der Leest
• How To Use Testosterone, Peptide Stacks That Will Blow Your Thoughts, The Reality About Getting Peptides On The Web, & A lot Extra With Jay Campbell.

The “Lean and Imply” Peptide Stack (Muscle Acquire & Fats Loss)

As I’ve said many, many instances all through my profession, muscle mass shouldn’t be solely useful for staying robust and searching good bare ;), it’s additionally important to sustaining a protracted and wholesome life.

So, in the event you’re fascinated about getting larger, stronger, sexier, and sooner with age—along with lifting heavy issues, consuming enough protein, and avoiding inflammatory meals—peptides might be one other software in your toolkit that will help you concurrently construct muscle and burn fats.

(P.S.: This stack would work wonders when mixed with the train, life-style, and biohacking suggestions coated in my article “Horny Ceaselessly: How To Construct Purposeful, Good-Trying Muscle For Life”). I notably like this one for morning fasted exercises.

This muscle acquire/fats loss stack contains the next peptides: IGF-1 LR3, ipamorelin, CJC-1295 (with out DAC), and tesamorelin.

IGF-1 LR3

There are principally two mechanisms by which you’ll enhance muscle mass: hypertrophy (enhance in muscle fiber measurement) or hyperplasia (enhance in muscle fiber quantity).

IGF-1 LR3, which is actually the long-acting model of IGF-1, a potent anabolic peptide, works to extend muscle by stimulating hyperplasia.

• Dosing Pointers:
  • 50–150mcg 1x/day for a 4-week cycle; OR
  • 4mL of 620mcg/mL answer 1x/day
• Administration Route:

Ipamorelin

As a result of it will increase development hormone (GH) secretion, Ipamorelin can also be a potent muscle-building peptide. GH has main results on skeletal muscle and performance, which is why it’s such a extensively used (and abused) sports activities efficiency drug.

• Dosing Pointers:
  • 100–500mcg 1–3x/day for a 12-week cycle; OR
  • 10mL of 2000mcg/mL answer 1x/day, 5 days per week
• Administration Route:
• Timing Ideas:
  • For muscle acquire/fats loss, I’ve personally seen the most effective outcomes utilizing ipamorelin earlier than bedtime on an empty abdomen.

CJC-1295 with out DAC (Modified GRF 1-29)

CJC-1295 features as a development hormone-releasing hormone (GHRH) and will increase IGF-1, which helps promote fats loss and elevated muscle protein synthesis.

For this stack, you’ll need to use CJC with out DAC (drug affinity advanced), which is the shorter-acting model that extra carefully mimics your physique’s pure development hormone pulses.

• Dosing Pointers:
  • 100mcg 1–3x/day for a 12-week cycle; OR
  • 10mL of 2000mcg/ml answer 1x/day, 5 nights per week
• Administration Route:
• Timing Ideas:
  • Take CJC-1295 earlier than bedtime on an empty abdomen.

Tesamorelin

Tesamorelin’s mechanism of motion is similar to that of ipamorelin; it really works on development hormone pathways and stimulates IGF-1, which triggers the manufacturing of muscle protein. It’s additionally been proven in giant medical trials to lower visceral fats and cut back ranges of triglyceride within the blood.

• Dosing Pointers:
  • 1mg 1–2x/day for five days per week; OR
  • 5mL of 1mg/0.6mL answer 1x/day, 6 days per week
• Administration Route:
• Timing Ideas:
  • For muscle acquire/fats loss, I’ve skilled the most effective outcomes by taking tesamorelin within the morning earlier than my fasted exercise. However it’s also possible to take it earlier than mattress, a minimum of 90 minutes after consuming.

Sources to be taught extra about these particular peptides:

The “By no means Get Sick” Immunity Peptide Stack

It’s possible you’ll be, like me, pulling out all of the stops to bolster your immune techniques lately.

Peptides might be extremely efficient for concentrating on the multi-faceted immune system—which incorporates many organs, cells, and signaling molecules—offering you with well-rounded help to fight no matter comes your means.

(P.S.: This stack could be glorious for supporting your immune system when mixed with the opposite options in my article, “Three Little Identified, Unconventional Antiviral Approaches For Boosting Your Immune System.”)

This immune-boosting stack contains the next peptides: TB-500, thymalin, and LL-37.

TB-500 (Thymosin Beta-4)

You don’t hear about it a lot, however the humble thymus gland is crucial in creating your immune system. Thymosin beta-4, a peptide produced by this gland, performs a big position in regulating immunity and producing white blood cells, lymphocytes, T cells, B cells, and antibodies.

• Dosing Pointers: There are only a few tips round dosing TB-500, so it’s greatest to observe your practitioner or producer’s options. Nevertheless, here’s what I’ve used:
  • 750mcg 1x/day, cycle for 3 months on/3 months off; OR
  • 3mg each different day, cycle for 3 months on/3 months off; OR
  • 25mL of 3000mcg/mL answer every day for a 20-day cycle
• Administration Route:

Thymalin

Thymalin is yet one more immune-boosting peptide produced by the thymus gland. It has immunomodulatory properties and performs a task in Th1 cytokine manufacturing (proinflammatory) and T cell (cell-mediated immunity) manufacturing and performance, each of that are very important for antiviral protection.

• Dosing Pointers:
  • 5–10mg 1x/day for 3-10 days, repeat each 6–12 months
• Administration Route:
  • Subcutaneous or intramuscular injection

LL-37

Analysis on this so-called “antimicrobial peptide” signifies that it additionally has antibiotic, antifungal, and antiviral properties. Thus, it might be extremely efficient for autoimmune points and intestine circumstances, together with fungal and bacterial overgrowth.

Warning: You probably have SIBO, the die-off and Jarisch-Herxheimer Response from LL-37 might be uncomfortable and should contain flu-like signs and diarrhea for as much as two weeks. After that, nonetheless, many individuals expertise the whole decision of SIBO signs and the elimination of bloating and gasoline in response to carbohydrate consumption.

• Dosing Pointers:
  • 100mcg 2x/day for 4–6 weeks
• Administration Route:

Sources to be taught extra about these particular peptides:

The “Benjamin Button” Anti-Growing older & Longevity Peptide Stack

Certainly one of my private favourite methods to stack peptides is to “sluggish the getting old course of” and promote longevity—principally turning me right into a real-life Benjamin Button.

All joking apart, there’s critically compelling analysis related to peptides and getting old. One principle, postulated by Professor Vladimir Khavinson, who is probably essentially the most distinguished medical gerontology researcher in Russia, is that lots of the woes of getting old are as a result of slow-bleed, steady breakdown of proteins (keep in mind: proteins are manufactured from peptide chains) in tissues and organs, which ends up in their eventual degradation and full-body getting old.

Nevertheless, if you replenish your peptide shops, they’re capable of restimulate protein synthesis in tissues. Because of this as a substitute of experiencing protein degradation and organ breakdown with age, peptides allow you to really restore as you grow old. Fairly cool, proper?

This anti-aging stack contains the next peptides: epithalon, thymalin, GHK-Cu, MOTS-C, humanin, and FOXO4-DRI.

Epithalon

Epithalon (additionally confusingly known as epitalon, no “h”) is often known as the “main anti-aging peptide” as a result of it is among the only a few synthesized compounds that has been proven to immediately activate the telomerase enzyme in people. Telomerase renews and elongates telomeres, the caps on the ends of chromosomes that defend DNA from injury and cancer-causing errors. By activating telomerase, epithalon can cut back the shortening of telomeres, theoretically serving to you “age backward.”

I personally use the “Khavinson Protocol” for dosing epithalon (sure, the exact same aforementioned professor), which makes use of the precise dosage from a fifteen-year longevity examine in people that produced spectacular outcomes for controlling telomere shortening.

• Dosing Pointers:
  • Khavinson Protocol: 5–10mg 3x/week for 3 weeks, cycle 1x/12 months; OR
  • 1mL of 3000mcg/mL answer, 1x/day
• Administration Route:
• Timing Ideas:
  • Epithalon is greatest administered within the morning.

Thymalin

Thymalin is a peptide produced by the thymus and pineal gland. It has a optimistic impact on nearly each system within the physique, together with the immune, cardiovascular, endocrine, and nervous techniques.

This peptide can also be believed to have the ability to delay human life, which is why it’s an vital a part of this longevity stack. A 2003 examine discovered that 2–3 years of therapy with thymalin was proven to scale back all-cause mortality for aged volunteers by an element of two!

• Dosing Pointers:
  • 5–10mg 1x/day for 10 days, cycle 1–2x/12 months
• Administration Route:
  • Subcutaneous or intramuscular injection

GHK-Cu

GHK-Cu helps to maintain you younger and supple in plenty of methods, together with selling wound therapeutic and tissue regeneration (pores and skin, hair follicles, abdomen, bone tissue), growing collagen and glycosaminoglycans, selling blood vessel development, possessing antioxidant and anti inflammatory results, and far more.

This peptide can be utilized topically/transdermally—reminiscent of in skincare or hair regrowth formulation—or injected for systemic results.

• Dosing Pointers:
  • Injection: 0.2mL of 100mg/mL, 1x/day
  • Transdermal: 1mL utilized 1x/day at evening
• Administration Route:
  • Subcutaneous injection for systemic results
  • Transdermal software for topical results (hair, pores and skin)

MOTS-c

Anti-aging researchers at the moment are conscious of the potent position metabolic well being and mitochondria play in longevity. MOTS-c is one peptide that powerfully impacts each of those elements, serving as a potent metabolic regulator that may improve autophagy, restore mitochondrial perform, and enhance insulin sensitivity.

It’s additionally been known as “train in a bottle” as a result of it may well mimic a number of the results of train by activating the AMP-Ok pathway.

• Dosing Pointers:
  • 10mg 1x/week for 10 weeks, 1x/12 months
• Administration Route:
• Timing Ideas:
  • For added mitochondrial profit, administer MOTS-c proper earlier than endurance train, ideally within the morning.

Humanin

Humanin is one other mitochondrial peptide and has been proven to produce robust cytoprotective actions in opposition to quite a lot of stressors and age-related illnesses, together with neurological problems, mitochondrial dysfunction, oxidative stress, hypoxic injury to the mind, and oxidized LDL ldl cholesterol.

Apparently, kids of centenarians (people that dwell to be over 100 years outdated) have unusually excessive ranges of humanin—a possible Fountain of Youth, maybe?

• Dosing Pointers: There are only a few tips round dosing humanin so it’s greatest to observe your practitioner or producer’s options. Nevertheless, right here is the vary I’ve seen beneficial (I might not counsel exceeding 0.04mg/kg physique weight per day).
  • 1–1.0mg 1–2x/day for a 2–8 week cycle, 1x/12 months
• Administration Route:

FOXO4-DRI

FOXO4-DRI (D-retro inversion isoform) is a cell-penetrating peptide that’s been proven in mice to selectively trigger destruction, or induce apoptosis, of senescent cells. Senescent cells cease multiplying however they don’t die off when they need to, which may result in extra irritation and accelerated getting old. In actual fact, mobile senescence has been tied to plenty of age-related circumstances like most cancers, diabetes, osteoporosis, Alzheimer’s, and dementia. So by selectively concentrating on these senescent cells, FOXO4 can assist cut back the danger of illnesses associated to getting old. Fairly cool!

• Dosing Pointers:
  • 3mg each different day for six days, repeat 1–3x/12 months
• Administration Route:

Sources to be taught extra about these particular peptides:

Abstract

So, there you’ve it.

You are formally geared up with a number of the most potent peptide stacks on the market for recovering sooner, constructing muscle and dropping fats, having a rock-solid immune system, and dwelling a protracted, wholesome life.

To be trustworthy, I want I had this information once I was first tinkering with peptides a number of years in the past—it positive would have saved me an entire heck of plenty of time, cash, and self-experimentation. Hopefully, you discover it as useful as I might have again then!

In the event you’re fascinated about any of the peptides talked about above (from trusted, respected sources) it’s also possible to take a look at my Peptides Sources Web page.

In abstract…

To “get better like Wolverine,” you may stack:

If you wish to lose fats and acquire muscle, mix these peptides:

For enhancing your immune system, strive stacking:

Lastly, to age gracefully and with an excellent healthspan and lifespan, use this final anti-aging peptide stack:

Keep in mind: In the event you want data on sourcing, administration, reconstitution, or different suggestions for getting began, make sure to take a look at this text, as nicely.

Moreover, if you wish to take your well being optimization to the following stage, contemplate diving deeper into the methods and insights shared above in my model new, not too long ago up to date, best-selling e-book, Boundless (you may pre-order your copy now!). In Boundless, you will discover complete steerage on enhancing mitochondrial perform, optimizing circadian rhythms, and bettering sleep, amongst different superior methods for enhancing your well being and longevity. Whether or not you are fascinated about sensible medication, peptides, or cutting-edge wellness practices, this e-book covers all of it, offering actionable methods to raise your bodily and psychological well-being.

And, as at all times, I might love to listen to your ideas, questions, and suggestions, so be at liberty to drop me a line within the feedback part beneath, and I am going to make sure to reply!